At least eight first-team members will be absent, seven through injury and Jordan Thorniley with concussion.
With that in mind, here’s how we think the Seasiders might line up at the DW Stadium...
7. CM - Charlie Patino
Fingers crossed the Arsenal loanee is back feeling 100% after recently suffering with a sickness bug. Photo: CameraSport - Rich Linley
8. CM - Sonny Carey
Carey was probably the only player to emerge with any credit from Blackpool's sobering midweek defeat. Photo: CameraSport - Dave Howarth
9. RW - CJ Hamilton
Theo Corbeanu is likely to drop out again after his poor midweek display, so CJ could come back in although Shayne Lavery is also an option. Photo: CameraSport - Rich Linley
10. LW - Jerry Yates
Yates is another certainty to start given Blackpool's lack of goals in recent weeks. He at least gave everything for the cause in midweek. Photo: CameraSport - Dave Howarth
11. ST - Gary Madine
The striker will need to deliver one final big shift before the break against a Wigan side that threaten from getting set-pieces into the box. Photo: CameraSport - Rich Linley