LINE UPS: Aimson keeps place in Pool side
It means Will Aimson retains his spot in a three-man defence, with Kelvin Mellor and Andy Taylor taking up the two wing-back spots.
Skipper Danny Pugh remains on the bench with Jim McAlister, Jack Payne and Brad Potts playing in a midfield three.
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Hide AdKyle Vassell, who will be looking for his first goal in seven games, starts up top alongside Mark Cullen.
Colin Daniel remains out of contention as he continues his comeback from a hamstring strain.
Today's league game comes after Blackpool drew 0-0 with Barnsley in the third round of the FA Cup last Saturday, followed by a penalty shootout defeat to Wycombe in the Checkatrade Trophy on Tuesday.
Cambridge, meanwhile, narrowly lost 2-1 to Leeds United in the FA Cup on Monday.
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Hide AdCambridge: Norris, Taylor, Legge, Roberts, Carroll, Mingoia, Dunne, Clark, Berry, Maris, Ikpeazu
Subs: Gregory, Adams, Pigott, Lewis, Newton, Williamson
Blackpool: Slocombe, Mellor, Aldred, Aimson, Robertson, Taylor, McAlister, Payne, Potts, Vassell, Cullen
Subs: Lyness, Pugh, Yeates, Osayi-Samuel, Philliskirk, Matt, Gnanduillet
Referee: Darren Drysdale